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Science Immunology

Article Metrics

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Overview of attention for article published in Science Immunology, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

news
4 news outlets
blogs
1 blog
twitter
78 tweeters
facebook
1 Facebook page
googleplus
2 Google+ users

Citations

dimensions_citation
262 Dimensions

Readers on

mendeley
271 Mendeley
Title
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
Published in
Science Immunology, August 2018
DOI 10.1126/sciimmunol.aar6676
Pubmed ID
Authors

Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder

Abstract

Neutrophil extrusion of neutrophil extracellular traps (NETs) and concomitant cell death (NETosis) provides host defense against extracellular pathogens, whereas macrophage death by pyroptosis enables defense against intracellular pathogens. We report the unexpected discovery that gasdermin D (GSDMD) connects these cell death modalities. We show that neutrophil exposure to cytosolic lipopolysaccharide or cytosolic Gram-negative bacteria (Salmonella ΔsifA and Citrobacter rodentium) activates noncanonical (caspase-4/11) inflammasome signaling and triggers GSDMD-dependent neutrophil death. GSDMD-dependent death induces neutrophils to extrude antimicrobial NETs. Caspase-11 and GSDMD are required for neutrophil plasma membrane rupture during the final stage of NET extrusion. Unexpectedly, caspase-11 and GSDMD are also required for early features of NETosis, including nuclear delobulation and DNA expansion; this is mediated by the coordinate actions of caspase-11 and GSDMD in mediating nuclear membrane permeabilization and histone degradation. In vivo application of deoxyribonuclease I to dissolve NETs during murine Salmonella ΔsifA challenge increases bacterial burden in wild-type but not in Casp11-/- and Gsdmd -/- mice. Our studies reveal that neutrophils use an inflammasome- and GSDMD-dependent mechanism to activate NETosis as a defense response against cytosolic bacteria.

Twitter Demographics

The data shown below were collected from the profiles of 78 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 271 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 271 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 22%
Researcher 48 18%
Student > Master 37 14%
Student > Bachelor 20 7%
Other 15 6%
Other 44 16%
Unknown 48 18%
Readers by discipline Count As %
Immunology and Microbiology 71 26%
Biochemistry, Genetics and Molecular Biology 54 20%
Agricultural and Biological Sciences 40 15%
Medicine and Dentistry 25 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 20 7%
Unknown 54 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2020.
All research outputs
#402,739
of 21,744,520 outputs
Outputs from Science Immunology
#292
of 796 outputs
Outputs of similar age
#9,659
of 298,682 outputs
Outputs of similar age from Science Immunology
#9
of 26 outputs
Altmetric has tracked 21,744,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 796 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 129.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,682 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.